Lu Research Group

[88] Shuo Wang, Zi-You Tian and Hua Lu* “Recyclable Polythioesters and Poly(thioester-co-peptoid)s via Ring-Opening Cascade Polymerization of Amino Acid N-Carboxyanhydrides”, Angew. Chem. Int. Ed. 2024, e202411630. [PDF] 

 

[87] Yangyang Sun, Zesheng An, Yanshan Gao, Rongrong Hu, Ye Liu, Hua Lu, Xiao-Bing Lu, Xuan Pang, Anjun Qin, Yong Shen, Youhua Tao, Yu-Zhong Wang, Junpeng Wang, Gang Wu, Guang-Peng Wu, Tie-Qi Xu, Xing-Hong Zhang, Yuetao Zhang, Zhenbiao Zhang, Jian-Bo Zhu, Miao Hong,* and Zhibo Li* “New sustainable polymers with on-demand depolymerization property”, Sci. China Chem. 2024, 67, 2803-2841. [PDF]

[86] Wei Xiong, Tianjun Yue, Haiwang Lai, Chunyan Lyu, Weimin Ren,* and Hua Lu* “Synthesis of poly(thiourethane-alt-thioester) by alternating ring-opening copolymerization of N-thiocarboxyanhydrides and episulfides”, Sci. China Chem. 2024, 67, 3091-3097. [PDF]

 

[85] Xiaodong Jing,† Zhen Zhu,† Shuo Wang, Jiaqi Xin, Haisen Zhou, Letian Wang, Huimin Tong, Chenhui Cui, Yanfeng Zhang, Fei Sun, Lijiang Yang,* Yiqin Gao,* and Hua Lu* “Nonionic Water-Soluble Oligo(ethylene glycol)-Modified Polypeptides with a β-Sheet Conformation”, Biomacromolecules. 2024, 25, 5343-5351. (†equal contribution) [PDF]

 

[84] Yi Zhang,† Xuemei Wang,† Jun Lin,† Jia Liu,† Kai Wang, Qixing Nie, Chuan Ye, Lulu Sun, Yanpeng Ma, Ruize Qu, Yuejian Mao, Xuguang Zhang, Hua Lu, Pengyan Xia, Dongyu Zhao, Guang Wang*, Zhipeng Zhang,* Wei Fu,* Changtao Jiang,* and Yanli Pang* “A microbial metabolite inhibits the HIF-2a-ceramide pathway mediates the beneficial effects of time-restricted feeding on MASH”, Cell Metab. 2024, 36, 1823-1838. (†equal contribution) [PDF]

 

[83] Xin Hong*, Qi Yang*, Kuangbiao Liao*, Jianfeng Pei*, Mao Chen*, Fanyang Mo*,Hua Lu*, Wen-Bin Zhang*, Haisen Zhou, Jiaxiao Chen, Lebin Su, Shuo-Qing Zhang, Siyuan Liu, Xu Huang, Yi-Zhou Sun, Yuxiang Wang, Zexi Zhang, Zhunzhun Yu, Sanzhong Luo*, Xue-Feng Fu* and Shu-Li You* “AI for organic and polymer synthesis”, Sci. China Chem. 2024, 67, 2461-2496. [PDF]

[82] Qixing Nie,† Xi Luo,† Kai Wang,† Yong Ding,† Shumi Jia,† Qixiang Zhao,Meng Li, Jinxin Zhang, Yingying Zhuo, Jun Lin, Chenghao Guo, Zhiwei Zhang, Huiying Liu, Guangyi Zeng, Jie You, Lulu Sun, Hua Lu, Ming Ma, Yanxing Jia,* Ming-Hua Zheng* Yanli Pang,* Jie Qiao,* and Changtao Jiang* “Gut symbionts alleviate MASH through a secondary bile acid biosynthetic pathway”, Cell. 2024, 187, 2717-2734. (†equal contribution) [PDF]

 

[81] Shuo Wang, Ming-Yuan Lu, Si-Kang Wan, Chun-Yan Lyu, Zi-You Tian, Kai Liu, and Hua Lu*, “Precision Synthesis of Polysarcosine via Controlled Ring-Opening Polymerization of N-Carboxyanhydride: Fast Kinetics, Ultrahigh Molecular Weight, and Mechanistic Insights”, J. Am. Chem. Soc. 2024, 146, 5678-5692. [PDF]

 

[80] Jianhua Lu, Yuanhao Dai, Yahui He, Ting Zhang, Jing Zhang, Xiangmei Chen, Changtao Jiang, and Hua Lu*, “Organ/Cell-Selective Intracellular Delivery of Biologics via N-Acetylated Galactosamine-Functionalized Polydisulfide Conjugates”, J. Am. Chem. Soc. 2024, 146, 3974-3983. [PDF]

 

[79] Jialing Sun†, Junyi Chen†, Yiming Sun, Yingqin Hou, Zhibo Liu*, and Hua Lu*, “On the origin of the low immunogenicity and biosafety of a neutral α-helical polypeptide as an alternative to polyethylene glycol”, Bioactive Mater. 2024, 32, 333-343. (†equal contribution) [PDF]

 

[78] Yi Zhang, Hua Lu,* “Ring-Opening Copolymerization of Hydroxyproline-Derived Thiolactones and Lipoic Acid Derivatives”, Polym. Chem., 2023, 14, 3813-3820. [PDF]

 

[77] Zhengchu Zhang, Wei Xiong*, and Hua Lu*, “Preparation and Material Properties ofα-Helical Polypeptides Crosslinked Hydrogel”, Acta Chim. Sinica 2023, 81, 1113-1119.

    张正初，熊炜*，吕华*，α-螺旋聚氨基酸交联的水凝胶的制备和材料特性，化学学报，2023, 81, 1113-1119. [PDF]

[76] Chunyan Lyu, Wei Xiong, Er-Qiang Cheng*, and Hua Lu*, “Structure-Property Relationship Analysis of D-Penicillamine-Derived β-Polythioesters with Varied Alkyl Side Groups”, Chin. J. Polym. Sci. 2023, 41, 1555-1562. [PDF]

 

[75] Zhuanglin Shen, Yiming Sun, Guoliang Zhu, Gaixia Xu, Zhenqiang Yu, Hua Lu*, and Yantao Chen*, “Molecular Insights into the Improved Bioactivity of Interferon Conjugates Attached to a Helical Polyglutamate”, Langmuir 2023, 39, 6539-6547.  [PDF]

 

[74] Guangqi Wu, Haisen Zhou, Jun Zhang, Zi-You Tian, Xingyi Liu, Shuo Wang, Connor W. Coley, and Hua Lu*, “A high-throughput platform for efficient exploration of functional polypeptide chemical space”, Nat. Synth. 2023, doi: 10.1038/s44160-023-00294-7.  [PDF] 

[73] Shuo Wang, and Hua Lu*, “Ring-Opening Polymerization of Amino Acid N-Carboxyanhydrides with Unprotected/Reactive Side Groups. I. _D-Penicillamine N-Carboxyanhydride”, ACS Macro Lett. 2023, 12, 555-562.  [PDF]

[72] Guo-Qing Jin; Jing-Xiang Wang; Jianhua Lu; Hang Zhang; Yuhang Yao; Yingying Ning; Hua Lu; Song Gao; Jun-Long Zhang* “Two birds one stone: β-fluoropyrrolyl-cysteine S_NAr chemistry enabling functional porphyrin bioconjugation”, Chem. Sci. 2023, 14, 2070-2081.  [PDF]

[71] Wei Xiong, and Hua Lu*, “Recyclable polythioesters and polydisulfides with near-equilibrium thermodynamics and dynamic covalent bonds”, Sci. China. Chem. 2023, 66, 725-738 (Invited Review). [PDF]

[70] Jianhua Lu, Zhun Xu, Hailin Fu, Yao Lin, Huan Wang, Hua Lu^*, “Room-temperature grafting from synthesis of protein–polydisulfide conjugates via aggregation-induced polymerization”, J. Am. Chem. Soc. 2022, 144, 15709-15717. [PDF]

 

[69] Yali Hu, Zi-You Tian, Wei Xiong, Dedao Wang, Ruichi Zhao, Yan Xie, Yu-Qin Song, Jun Zhu, Hua Lu^*, “Water-assisted and protein-initiated fast and controlled ring-opening polymerization of proline N-carboxyanhydride”, Natl. Sci. Rev. 2022, nwac033. [PDF]

[68] Yi Zhang, Hua Lu^*, “Synthesis and applications of hydroxyproline-derived thermoplastic elastomers”, Acta Polym. Sinica 2022, 53, 1123-1130. [PDF]

[67] Haisen Zhou^†, Yaoyi Wang^†, Yingqin Hou, Zhengkui Zhang, Qi Wang, Xiaodong Tian^*, Hua Lu^*, “Co-delivery of cisplatin and chlorin e6 by poly(phosphotyrosine) for synergistic chemotherapy and photodynamic therapy”, Chin. J. Chem. 2022, 40, 2428-2436. (^†equal contribution) [PDF]

 

[66] Chenglong Ge^†, Junliang Zhu^†, Guangqi Wu, Yuan He, Hua Lu^*, Lichen Yin^*, “ROS-responsiveness selenopolypeptide micelles: Peparation, characterization, and controlled drug release”, Biomacromolecules 2022, 23, 2647-2654. (^†equal contribution) [PDF]

 

[65] Meng Yang^†, Zheng-Chu Zhang^†, Fu-Zhen Yuan^†, Rong-Hui Deng, Xin Yan, Feng-Biao Mao, You-Rong Chen^*, Hua Lu^*, Jia-Kuo Yu^*, “An Immunomodulatory Polypeptide Hydrogel for Osteochondral Defect Repair”, Bioactive Materials 2023, 19, 678-689. (^†equal contribution) [PDF]

 

[64] Zhang Chong,  Hua Lu*, “Helical Nonfouling Polypeptides for Biomedical Applications”, Chinese J. Polym. Sci. 2022, 40(5), 433-446. [PDF]

 

 

[63] Chao Dong^†, Guangqi Wu^†, Chen Chen, Xia Li, Rui Yuan, Liang Xu, Hui Guo, Jay Zhang, Hua Lu*, Feng Wang*, “Site-Specific Conjugation of a Selenopolypeptide to Alpha-1-antitrypsin Enhances Oxidation Resistance and Pharmacological Properties”, Angew. Chem. Int. Ed. 2022, 61, e202115241. (^†equal contribution) [PDF]

 

[62] Haisen Zhou, Yaoyi Wang, Hua Lu*, "Intracellular delivery of His-tagged proteins via a hybrid organic–inorganic nanoparticle", Polym. J. 2021, 53, 1259-1267. [PDF]

[61] Zi-You Tian, Zhengchu Zhang, Shuo Wang, Hua Lu*, “A moisture-tolerant route to unprotected α/β-amino acid N-carboxyanhydrides and facile synthesis of hyperbranched polypeptides”, Nat. Commun. 2021, 12, 5810. [PDF]

 

[60] Qingxin Yao^†, Guangqi Wu^†, Hao Hao^†, Hua Lu^*, and Yuan Gao^*, “Redox-mediated reversible supramolecular assemblies driven by switch and interplay of peptide secondary structures”, Biomacromolecules 2021, 22, 2563-2572. (^†equal contribution) [PDF]

[59] Zi-You Tian, Shuo Wang, and Hua Lu^*, “Hydroxyproline-derived biomimetic and biodegradable polymers”, Curr. Opin. Solid State Mater. Sci. 2021, 25, 100902 (Invited Review) [PDF]

[58] Yali Hu, Dedao Wang, Hao Wang, Ruichi Zhao, Yaoyi Wang, Yunfei Shi, Jun Zhu, Yan Xie*, Yu-Qin Song*, Hua Lu*, “An urchin-like helical polypeptide-asparaginase conjugate with mitigated immunogenicity”, Biomaterials 2021, 268, 120606. [PDF]  

[57] Hao Wang, Yali Hu, Yaoyi Wang, Jianhua Lu, Hua Lu*, “Doxorubicin@ PEPylated interferon-polydisulfide: A multi-responsive nanoparticle for enhanced chemo–protein combination therapy”, Giant 2021, 5, 100040. [PDF]  

[56] Wei Xiong, Wenying Chang, Dong Shi, Lijiang Yang, Ziyou Tian, Hao Wang, Zhengchu Zhang, Xuhao Zhou, Er-Qiang Chen,* and Hua Lu*, “Geminal Dimethyl Substitution Enables Controlled Polymerization of Penicillamine-Derived β-Thiolactones and Reversed Depolymerization”, Chem 2020, 6, 1831-1843. [PDF]  (Highlighted by Chem in the same issue)

[55] Yong Shen, Wei Xiong, Yongzheng Li, Zhichao Zhao, Hua Lu* & Zhibo Li*, "Chemoselective Polymerization of Fully Biorenewable α-Methylene-γ-Butyrolactone Using Organophosphazene/Urea Binary Catalysts Toward Sustainable Polyesters", CCS Chem. 2020, 2, 620–630. [PDF]

[54] Helen Yao,‡ Kai Sheng,‡ Jialing Sun, Shupeng Yan, Yingqin Hou, Hua Lu and Bradley D. Olsen *, "Secondary structure drives self-assembly in weakly segregated globular protein-rod block copolymers", Polym. Chem., 2020, 11(17), 3032-3045.(‡equal contribution) [PDF]

 

[53] Jingsong Yuan, Dong Shi, Yi Zhang, Jianhua Lu, Letian Wang, Er-Qiang Chen,* and Hua Lu*, “4-Hydroxy-L-Proline as a General Platform for Stereoregular Aliphatic Polyesters: Controlled Ring-Opening Polymerization, Facile Functionalization, and Site-Specific Bioconjugation”, CCS Chem. 2020, 2, 236-244. [PDF]

[52] Zhilei Ge,† Linjie Guo,† Guangqi Wu,† Jiang Li, Yunlong Sun, Yingqin Hou, Jiye Shi, Shiping Song, Lihua Wang, Chunhai Fan, Hua Lu,* and Qian Li*, “DNA Origami-Enabled Engineering of Ligand-Drug Conjugates for Targeted Drug Delivery”, Small. 2020, e1904857. (†equal contribution)  [PDF]

[51] Dongxiao Yin, Hao Wen, Guangqi Wu, Shaolu Li, Chengyang Liu, Hua Lu*, and Dehai Liang*, “Pegylated Gene Carriers in Serum under Shear Flow”, Soft Matter 2020, 16, 2301-2310. [PDF]

[50] Jianhua Lu, Hao Wang, Ziyou Tian, Yingqin Hou, and Hua Lu*, "Cryopolymerization of 1,2-Dithiolanes for the Facile and Reversible Grafting-from Synthesis of Protein−Polydisulfide Conjugates", J. Am. Chem. Soc. 2020, 142(3), 1217−1221. [PDF]

[49]​ Ruijue Wang†, Kai Sheng†, Yingqin Hou, Jialing Sun and Hua Lu*, "Tailoring Cationic Helical Polypeptides for Efficient Cytosolic Protein Delivery", Chem. Res. Chinese U., 2020, 36(1), 134-138. ( † equal contribution) [PDF]

[48] Wei Xiong, Chong Zhang, Xiaolin Lyu, Hantao Zhou, Wenying Chang, Yu Bo, Erqiang Chen*, Zhihao Shen* and Hua Lu*, "Synthesis of modifiable photo-responsive polypeptides bearing allyloxyazobenzene side-chains", Polym. Chem., 2020, 11, 439-448. [PDF]

[47] Hao Wang, Yingqin Hou, Yali Hu, Jiaxiang Dou, Youqing Shen, Yucai Wang*, and Hua Lu*, "Enzyme-Activatable Interferon−Poly(α-amino acid) Conjugates for Tumor Microenvironment Potentiation", Biomacromolecules 2019, 20, 3000−3008. [PDF]

[46] Guangqi Wu, Chenglong Ge, Xingyi Liu, Shuo Wang, Letian Wang, Lichen Yin* and Hua Lu*, "Synthesis of water soluble and multi-responsive selenopolypeptides via ring-opening polymerization of N-carboxyanhydrides", Chem. Commun., 2019, 55, 7860-7863. [PDF]

[45] Yingqin Hou and Hua Lu*, "Protein PEPylation: A New Paradigm of Protein−Polymer Conjugation“, Bioconjugate Chem. 2019, 30, 1604−1616. [PDF]

[44]​ Jingsong Yuan, Wei Xiong, Xuhao Zhou, Yi Zhang, Dong Shi, Zi-Chen Li, and Hua Lu*, “4-Hydroxyproline-Derived Sustainable Polythioesters: Controlled Ring-Opening Polymerization, Complete Recyclability, and Facile Functionalization”, J. Am. Chem. Soc. 2019, 141, 4928-4935. (ACS Editors’ Choice, Featured as the Front Cover, also highlighted in Spotlights on Recent JACS Publications) [PDF]

[43]​ Chong Zhang†, Jianhua Lu†, Falin Tian†, Lindong Li, Yingqin Hou, Yaoyi Wang, Lingdong Sun*, Xinghua Shi*, and Hua Lu*, “Regulation of the cellular uptake of nanoparticles by the orientation of helical polypeptides”, Nano Res., 2019, 12(4): 889–896 . (†equal contribution) [PDF]

[42]  Yingqin Hou,† Yu Zhou,† Hao Wang,† Jialing Sun,† Ruijue Wang,† Kai Sheng,† Jingsong Yuan,† Yali Hu,‡ Yu Chao,§ Zhuang Liu,§ and Hua Lu*,†, "Therapeutic Protein PEPylation: The Helix of Nonfouling Synthetic Polypeptides Minimizes Antidrug Antibody Generation", ACS Cent. Sci. 2019, 5, 229−236. [PDF]

[41] Shan Su†, Yaoyi Wang†, Fu-Sheng Du*, Hua Lu*, and Zi-Chen Li, “Dynamic Covalent Bond-Assisted Programmed and Traceless Protein Release: High Loading Nanogel for Systemic and Cytosolic Delivery”, Adv. Funct. Mater. 2018, 28, 1805287. (†equal contribution) [PDF]

[40] Jingsong Yuan, Yi Zhang, Zezhou Li, Yaoyi Wang, and Hua Lu*, “A S-Sn Lewis Pair-Mediated Ring-Opening Polymerization of α-Amino Acid N-Carboxyanhydrides: Fast Kinetics, High Molecular Weight, and Facile Bioconjugation”, ACS Macro Lett. 2018, 7, 892-897. [PDF]

[39] Yali Hu, Yingqin Hou, Hao Wang, and Hua Lu*, “Polysarcosine as an Alternative of PEG for Therapeutic Protein Conjugation”, Bioconjugate Chem. 2018, 29, 2232-2238. [PDF]

[38] Chong Zhang†, Jianhua Lu†, Yingqin Hou, Wei Xiong, Kai Sheng, and Hua Lu*, “Investigation on the Linker Length of Synthetic Zwitterionic Polypeptides for Improved Nonfouling Surfaces”, ACS Appl. Mater. Interfaces 2018, 10, 17463-17470. (†equal contribution)  [PDF]

[37] Jingsong Yuan, Yi Zhang, Yue Sun, Zhicheng Cai, Lijiang Yang*, and Hua Lu*, “Salt- and pH-Triggered Helix-Coil Transition of Ionic Polypeptides under Physiology Conditions”, Biomacromolecules 2018, 19, 2089-2097. [PDF]

 

 

[36] Chong Zhang, Jingsong Yuan, Jianhua Lu, Yingqin Hou, Wei Xiong, and Hua Lu*, “From Neutral to Zwitterionic Poly(α-Amino Acid) Nonfouling Surfaces: Effects of Helical Conformation and Anchoring Orientation”, Biomaterials 2018, 178, 728-737. [PDF]

[35] Yingqin Hou, Yu Zhou, Hao Wang, Ruijue Wang, Jingsong Yuan, Yali Hu, Kai Sheng, Juan Feng, Shengtao Yang and Hua Lu*, “Macrocyclization of Interferon–Poly(α-amino acid) Conjugates Significantly Improves the Tumor Retention, Penetration, and Antitumor Efficacy”, J. Am. Chem. Soc., 2018, 140, 1170-1178. [PDF]

[highlighted by ACS Chemical & Engineering News]

[34] Chong Zhang and Hua Lu*, “Efficient Synthesis and Application of Protein-Poly(α-amino acid) Conjugates”, Acta Polymerica Sinica, 2018, 1, 21-31. [PDF]

[33] Shaolu Li†, Yaoyi Wang†, Jingfang Zhang, Wei Wei* and Hua Lu*, “Targeted delivery of a guanidine-pendant Pt(IV)-backboned poly-prodrug by an anisamide-functionalized polypeptide”, J. Mater. Chem. B, 2017, 5, 9546-9557. (†equal contribution) [PDF] 

[32] Wei Xiong, Hantao Zhou, Chong Zhang, Hua Lu*, “An amino acid-based gelator for injectable and multi-responsive hydrogel”, Chinese Chemical Letters, 2017, 28, 2125–2128. [PDF]

[31] Yingqin Hou†, Yaoyi Wang†, Ruijue Wang, Weier Bao, Xiaobo Xi, Yunlong Sun, Shengtao Yang, Wei Wei* and Hua Lu*, “Harnessing Phosphato-Platinum Bonding Induced Supramolecular Assembly for Systemic Cisplatin Delivery”, ACS Appl. Mater. Interfaces, 2017, 9 (21), 17757–17768. (†equal contribution) [PDF]

[30] Shaolu Li†, Yingqin Hou†, Yali Hu, Jin Yu, Wei Wei* and Hua Lu*, “Phosphatase-triggered cell-selective release of a Pt(IV)-backboned prodrug-like polymer for an improved therapeutic index”, Biomater. Sci. 2017, 5, 1558 – 1566. (†equal contribution) [PDF]

[29] Wei Xiong, Xiaohui Fu, Yaoming Wan, Yunlong Sun, Zhibo Li* and Hua Lu*, “Synthesis and multimodal responsiveness of poly(α-amino acid)s bearing OEGylated azobenzene side-chains”, Polym. Chem., 2016, 7, 6375-6382 [PDF]

[28] Yingqin Hou, † Jingsong Yuan, † Yu Zhou, Jin Yu, and Hua Lu*, “A Concise Approach to Site-Specific Topological Protein-Poly(amino acid) Conjugates Enabled by in Situ -Generated Functionalities”, J. Am. Chem. Soc. 2016, 138, 10995-11000. (†equal contribution) [PDF] 

[Highlighted by Acta Polymerica Sinica][Highlighted by X-MOL]

[27] Guangqi Wu, Hua Lu*, “Progress in Biomedical Applications of Functionalized Nucleic Acid Nanodevices (NANDs)”, ChemNanoMat 2016, 2, 354-363. [PDF]

[26] Jingsong Yuan, Yunlong Sun, Jingyu Wang, and Hua Lu*, “Phenyl Trimethylsilyl Sulfide-Mediated Controlled Ring-Opening Polymerization of α‐Amino Acid N‐Carboxyanhydrides”, Biomacromolecules, 2016, 17, 891-896. [PDF]

[25] Yunlong Sun, Yingqin Hou, Xuhao Zhou, Jingsong Yuan, Jingyu Wang, and Hua Lu*,”Controlled Synthesis and Enzyme-Induced Hydrogelation of Poly(L‑phosphotyrosine)s via Ring-Opening Polymerization of α‑Amino Acid N‑Carboxyanhydride” ACS Macro Letters  2015, 4,1000-1003. [PDF]

[24] Hua Lu†, Quan Zhou†, Vishal Deshmukh†, Hardeep Phull, Jennifer Ma, Virginie Tardif, Rahul R. Naik, Claire Bouvard, Yong Zhang, Seihyun Choi, Brian R. Lawson, Shoutian Zhu, Chan Hyuk Kim*, and Peter G. Schultz*, “Targeting Human C-Type Lectin-Like Molecule-1 (CLL1) with a Bispecific Antibody for Acute Myeloid Leukemia Immunotherapy”, Angew. Chem. Int. Ed. 2014, 53, 9841-9845. [PDF]

[23] Nan Zheng, Lichen Yin, Ziyuan Song, Liang Ma, Haoyu Tang, Nathan P. Gabrielson, Hua Lu,  and Jianjun Cheng*, “Maximizing gene delivery efficiencies of cationic helical polypeptides via balanced membrane penetration and cellular targeting”, Biomaterials, 2014, 35, 1302-1314. [PDF]

[22] Hua Lu*, Jing Wang, Ziyuan Song, Lichen Yin, Yanfeng Zhang, Haoyu Tang, Chunlai Tu, Yao Lin*and Jianjun Cheng*, ” Recent Advances in Amino Acid N-Carboxyanhydrides and Synthetic Polypeptides: Chemistry, Self-assembly and Biological Applications”, Chem. Comm. 2014, 50, 139-155. [PDF]

[21] Hua Lu, Danling Wang, Stephanie Kazane, Tsotne Javahishvili, Feng Tian, Frank Song, Aaron Sellers, Barney Barnett and Peter G. Schultz*, “Site-specific Antibody-polymer Conjugates for siRNA Delivery “, J. Am. Chem. Soc., 2013, 135, 13885–13891. [PDF]

[20] Yanfeng Zhang, Qian Yin, Hua Lu, and Honwgwei Xia, Yao Lin Jianjun Cheng*, “PEG-Polypeptide Dual Brush Block Copolymers: Synthesis and Application in anoparticle Surface PEGylation”,  ACS Macro. Lett. 2013, 2, 809-813 [PDF]

[19] Lichen Yin, Haoyu Tang, Kyung Kim, Nan Zheng, Ziyuan Song, Nathan Gabrielson, Hua Lu, and Jianjun Cheng*, “Light-Responsive Helical Polypeptides Capable of Reducing Toxicity and Unpacking DNA toward Non-Viral Gene Delivery” Angew. Chemie. Int. Ed. 2013, 52, 9182-9186. [PDF]

[18] Jing Wang, Hongwei Xia, Yanfeng Zhang, Hua Lu, Ranjan Kamat, Andrey V. Dobrynin, Jianjun Cheng* and Yao Lin*, “Nucleation-Controlled Polymerization of Nanoparticles into Supramolecular Structures”, J. Am. Chem. Soc., 2013, 135, 11417-11420. Featured as the cover art of Volume 135, Issue 31, August 7, 2013 [PDF]

[17] Jonathan Yen, Yanfeng Zhang, Nathan Gabrielson, Lichen Yin, Linna Guan, Isthier Chaudhury, Hua Lu, Fei Wang* and Jianjun Cheng*, “Cationic, helical polypeptide-based gene delivery for IMR-90 fibroblasts and human embryonic stem cell”, Biomater. Sci. 2013, 1, 719-727 [PDF]

[16] Lichen Yin, Ziyuan Song, Kyung Hoon Kim, Nan Zheng, Haoyu Tang, Hua Lu, Nathan Gabrielson, Jianjun Cheng*, “Reconfiguring the architectures of cationic helical polypeptides to control non-viral gene delivery”, Biomaterials 2013, 34, 2340-2349. [PDF]

[15] Haoyu Tang, Lichen Yin, Hua Lu, and Jianjun Cheng*, “Water-Soluble Poly(L-serine)s with Elongated and Charged Side-Chains: Synthesis, Conformations and Cell-Penetrating Properties”, Biomacromolecules 2012, 13, 2609-2615. [PDF]

[14] Nathan Gabrielson, Hua Lu, Lichen Yin, Kyung Hoon Kim and Jianjun Cheng*, “A Cell-Penetrating Helical Polymer for siRNA Delivery to Mammalian Cells “, Mol. Ther. 2012, 20, 1599-1609. [PDF]

[13] Nathan Gabrielson†, Hua Lu†, Lichen Yin, Dong Li, Fei Wang, and Jianjun Cheng*,”A Reactive Cationic α-Helical Polypeptide Template for Non-Viral Gene Delivery”, Angew. Chem. Int. Ed. 2012, 51, 1143-1147 (†equal contribution) highlighted by Chemical and Engineering News, issue of Dec. 19, 2011; reported by ScienceDaily, PhysOrg, and EurekAlert! etc. [PDF]

[12] Kuan-Ju Chen, Li Tang, Mitch Andre Garcia, Hao Wang, Hua Lu, Wei-Yu Lin, Shuang Hou, Qian Yin, Clifton K.-F. Shen, Jianjun Cheng* and Hsian-Rong Tseng*, “The therapeutic efficacy of camptothecin-encapsulated supramolecular nanoparticles”, Biomaterials 2012, 33, 1162-1169. [PDF]

[11] Hua Lu, Jing Wang, Yugang Bai, Jason Long, Shiyong Liu, Yao Lin* and Jianjun Cheng*, “Ionic Polypeptides with Unusual Helical Stability”, Nature Commun. 2011, 2, 206. Reported by NSF, ScienceDaily, PhysOrg, EurekAlert! and ChemistryViews etc. [PDF]

[10] Jing Wang, Hua Lu, Ranjan Kamat , Sai Venkatesh Pingali , Volker S. Urban, Jianjun Cheng* and Yao Lin*, “Supramolecular Polymerization from Polypeptide-Grafted Comb Polymers”, J. Am. Chem. Soc. 2011, 133, 12906-12909. Highlighted by Chemical and Engineering News, issue of Aug. 15, 2011. [PDF]

[9] Jing Wang, Hua Lu, Yuan Ren, Yanfeng Zhang, Martha Morton, Jianjun Cheng* and Yao Lin*, ” Interrupted Helical Structure of Grafted-Polypeptides in Brush-like Macromolecules”, Macromolecules 2011, 44, 8699-9709. [PDF]

[8] Hua Lu, Yugang Bai, Jing Wang, Yao Lin and Jianjun Cheng*, “Controlled Ring-Opening Polymerization of γ-(4-Vinylbenzyl)-L-Glutamate N-Carboxyanhydride for the Synthesis of Functional Polypeptides”, Macromolecules 2011, 44, 6237-6240; Featured as the cover art of Macromolecules, Volume 44, Issue16, August 23, 2011 [PDF]

[7] Yanfeng Zhang, Hua Lu, Yao Lin and Jianjun Cheng*, “Water-Soluble Polypeptides with Elongated, Charged Side Chains Adopt Ultrastable Helical Conformations”, Macromolecules 2011, 44, 6641-6644. [PDF]

[6] Yugang Bai, Hua Lu, Ettigounder Ponnusamy, and Jianjun Cheng*, “Synthesis of Hybrid Block Copolymers via Integrated Ring-Opening Metathesis Polymerization and Polymerization of NCA “, Chem. Comm. 2011, 47, 10830-10832. [PDF]

[5] Hua Lu, Jing Wang, Yao Lin* and Jianjun Cheng*, “One-Pot Synthesis of Brush-Like Polymers via Integrated Ring-Opening Metathesis Polymerization and Polymerization of Amino Acid N-Carboxyanhydrides”, J. Am. Chem. Soc. 2009, 131, 13582-13583. Highlighted by Chemical and Engineering News, issue of Sept. 14, 2009. [PDF]

[4] Hua Lu and Jianjun Cheng*, “N-Trimethylsilyl amines for controlled ring-opening polymerization of amino acid N-carboxyanhydrides and facile end group functionalization of polypeptides”, J. Am. Chem. Soc. 2008, 130, 12562-12563. [PDF]

[3] Hua Lu and Jianjun Cheng*, “Hexamethyldisilazane-Mediated Controlled Polymerization of alpha-Amino Acid N-Carboxyanhydrides”, J. Am. Chem. Soc. 2007, 129, 14115-14116. [PDF]

[2] Xiaoyu Cao, Hong Zi, Wei Zhang, Hua Lu, and Jian Pei*, “Star-shaped and Linear Nanosized Molecules Functionalized with Hexa-peri-hexabenzocoronene: Synthesis and Optical Properties” J. Org. Chem. 2005, 70, 3645-3653. [PDF]

[1] Xiaoyu Cao, Wenbin Zhang, Jinliang Wang, Xinhua Zhou, Hua Lu, and Jian Pei*, “Extended π–Conjugated Dendrimers Based on Truxene” J. Am. Chem. Soc. 2003, 125, 12430-12431. [PDF]